Predicting the Future: Phage Therapy

Phage therapy: past history and future prospects.

Bacterial viruses (bacteriophages, also called "phages") can be robust antibacterial agents in vitro. However, their use as therapeutic agents, during a number of trials from the 1920s to the 1950s, was greatly handicapped by a number of factors. In part, there were certain limitations inherent in phage physiology (e. g. narrow host range, and rapid clearance from the body); in part there were ...

Editorial: Phage Therapy: Past, Present and Future

Phage Therapy: Past History and Future Prospects R. M. Carlton: Phage Therapy in the Past and Future

Bacterial viruses (bacteriophages, also called “phages”) can be robust antibacterial agents in vitro. However, their use as therapeutic agents, during a number of trials from the1920s to the 1950s, was greatly handicapped by a number of factors. In part, there were certain limitations inherent in phage physiology (e. g. narrow host range, and rapid clearance from the body); in part there were t...

Phage in therapy and Prophylaxis History and Future Prospects

bacteriophages are well known in the biopharmaceutical industry, mainly due to their destructive impact on productivity of bacterialbased fermentations necessary for obtaining the product. however, it seems that their positive role may soon dominate their rather grim reputation in the biopharmaceutical industry. in this short editorial the reasons for the failure to fulfill the high hopes that ...

Predicting the future of anti-tumor necrosis factor therapy

Tumor necrosis factor (TNF) antagonists are approved worldwide for the treatment of rheumatoid arthritis (RA). Clinical experience revealed that TNF-blocking therapy is effective for only approximately two thirds of patients, reflecting that there are 'responders' as well as 'nonresponders'. Given the destructive nature of RA, the risk of adverse effects, and considerable costs for therapy, the...